A Quest Diagnostics study helps to answer the question: Can eating poppy seeds produce a positive drug test for a job applicant or employee? Getting ready to take a drug test for a job or for other reasons? Watch out for these common things that could lead to a false positive result. Can poppy seeds cause a positive anti-doping drug test? How does eating poppy seeds cause a failed drug test. Can you test positive after eating poppy seeds?
Challenging the poppy seed defense
The “poppy seed defense” or the claim that ingesting poppy seeds is the reason for a failed drug test has long been used to challenge drug test results. A Seinfeld episode brought it into the mainstream with a story line where Elaine Benes tests positive for opium on her company’s urine drug test and blames the result on her favorite breakfast, a poppy seed muffin.
In 2011, MythBusters, a Discovery Channel television program, told viewers that the myth was “definitely true” as producers ate poppy seed bread and bagels and then generated a positive result on an instant urine drug test. To date, there is limited research published about the impact of poppy seed consumption and opiate drug test results in controlled studies in alternative matrices such as oral fluid.
Poppy seeds & drug tests
We know poppy seeds contain opiates – specifically morphine and codeine. Ultimately, what employers want to understand from drug testing experts is: Can eating poppy seeds produce a positive drug test for a job applicant or employee?
Article in the Journal of Analytical Toxicology
In an article published in the October 2015 Society of Forensic Toxicologists (SOFT) Special Issue of the Journal of Analytical Toxicology, scientists from Quest Diagnostics compared the impact of the consumption of raw poppy seeds and a poppy containing food product on urine and oral fluid drug tests. For individuals performing safety-sensitive duties as well as other workers subject to routine drug testing for opiates, it is important to distinguish between dietary poppy seed ingestion and non-prescribed opiate or heroin abuse.
Study authors determined morphine and codeine concentrations using laboratory-based urine and oral fluid drug screening and confirmation methodologies after study participants ate a Ukrainian-style poppy seed roll and raw poppy seeds. By ingesting cooked and raw poppy seeds and then measuring drug concentrations over a series of intervals ranging from 15 minutes to 20 hours, the study showed a distinction between the source of poppy seeds ingested (i.e. raw or prepared) and the amount of time morphine and codeine were detected in both urine and oral fluid matrices.
Download the full article from the Journal of Analytical Toxicology.
What the research tells us
“The research tells us that it is possible to test positive on a drug test for morphine – even less so for codeine – after eating poppy seed-containing products. A unique characteristic of this study is that it compared the consumption of approximately the same amount of poppy seeds in both a prepared food item and as raw seeds and included the collection of both urine and oral fluid specimens. Unlike urine, the likelihood is much lower in oral fluid. Not surprisingly, most of the positive test findings and longest detection window resulted from ingestion of the large quantity of raw poppy seeds in a very short period of time prior to specimen collection. In fact, many of the study participants found such an amount of raw seeds to be extremely unpalatable. The results from this study suggest that there is less of a ‘poppy seed defense’ from a donor who completes an oral fluid drug test after casual dietary poppy seed consumption rather than a urine test because of the shorter detection window of oral fluid,” said Dr. Kimberly Samano.
Study authors include Dr. Kimberly L. Samano, Randal E. Clouette, Barbara J. Rowland, and Dr. Barry Sample.
What Can Cause a False Positive Drug Test
If you hang out often with someone who puffs on pot, your urine could have traces of THC. That’s the chemical in the cannabis plant that gets you high. But chances are very low that you’ll have enough THC to trigger the positive result in the screens used by the federal government and many private employers. That’s most likely to happen right after you’re exposed to the smoke. A second test would need to confirm it.
Weight Loss Pills
Phentermine is a prescription medicine that helps curb your appetite. It’s chemically similar to amphetamines, a stimulant used to treat ADHD and as a study aid to stay awake. Phentermine could raise a false red flag in your drug screen if you don’t have a medical reason for taking amphetamines.
These small black seeds naturally contain morphine and codeine. A poppy seed bagel, for example, might make you test positive for both of those opioids for up to a whole day after you eat it. That’s more likely to happen with labs that still follow the older, lower thresholds for detecting those substances.
Many liquid medications, vanilla extract, and breath-cleaning products often have ethanol, a form of simple grain alcohol. Today’s drug tests can detect even trace amounts of alcohol, and for longer after exposure. So if you use anything with ethyl alcohol, your breath, blood, or urine sample might get flagged for possible signs of drinking. The same thing could happen even with alcohol-based hand sanitizers if you use them regularly.
Sertraline (Zoloft) is prescribed for depression, panic attacks, obsessive-compulsive disorder, and more. Some drug screens may not be specific enough to tell apart sertraline and benzodiazepines. The latter is an older tranquilizer drug that’s often found in people who overdose on opioids. The faulty test result could happen for several days after you quit your antidepressant.
These medications usually won’t interfere with your drug screens. But in rare cases, a few antibiotics are known to trigger inaccurate test results. Rifampin, which treats tuberculosis, might show up as opiates in some rapid urine screens. What’s more, the false positive result may be possible even more than 18 hours after you’ve swallowed a single dose of the antibiotic.
Cannabidiol (CBD) comes from the hemp plant, a relative of the Cannabis sativa plant that produces marijuana. CBD, which doesn’t make you high, is used for medical marijuana to ease pain and other symptoms. Some states allow CBD oil, edibles, and other products to have up to 5% of the mind-altering chemical THC. Depending on when and how much you’ve taken CBD, it’s possible for your urine to show evidence of marijuana in your body.
Some popular over-the-counter allergy and sleep meds like Benadryl and Advil PM have diphenhydramine. It can relieve coughs and runny noses. But on drug screens, it can show up as methadone, which helps people quit heroin or other opiates and can be addictive. Diphenhydramine also may show up as PCP, an illegal hallucinogenic that is one of five types of drugs that applicants for all federal and many private-sector jobs are screened for.
Efavirenz (Sustiva) is an antiretroviral drug that helps treat your HIV infection. But on a drug screen, it can make you seem to have used marijuana. A second, more sensitive test should be able to distinguish which of the two compounds is in your body. To avoid confusion, you may want to alert the lab or the clinic beforehand that you’re on efavirenz.
This beverage is a popular folk remedy in Peru and elsewhere in South America. It’s made with the leaves of the same plant that cocaine comes from. If you drink it, you may want to stop a couple of days before your drug test. Coca tea could affect your screening for up to 36 hours after you’ve sipped it.
Several of these medications for mental disorders can lead to false positive tests. Quetiapine, which treats schizophrenia and bipolar disorder, can wrongly show that you have methadone in your urine. Another antipsychotic — chlorpromazine — can cause drug tests to come up positive for amphetamine, a stimulant.
IMAGES PROVIDED BY:
American Addiction Centers: “What’s An Amphetamine? Addiction: Signs, Symptoms, and Treatment.”
American Association for Clinical Chemistry: “Rifampin Interference with Opiate Immunoassays.”
Drug Enforcement Administration: “Dextromethorphan.”
FDA: “Zoloft (sertraline hydrochloride) Label.”
Journal of Analytical Toxicology: “Non-Smoker Exposure to Secondhand Cannabis Smoke. I. Urine Screening and Confirmation Results.”
Massachusetts Medical Society: “Urine Abstinence Testing And Incidental Alcohol Exposure.”
Mayo Clinic: “Urine Drug Screening: Practical Guide for Clinicians.”
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National Institute on Drug Abuse for Teens: “What is Hemp?”
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Pharmacokinetics in Psychiatry and Neurology: “Urine drug screens: Considerations for the psychiatric pharmacist.”
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The Brookings Institution: “The Farm Bill, hemp legalization and the status of CBD: An explainer.”
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University of Florida: “Germ-killing sanitizers could have effect on alcohol tests.”
American Alliance Drug Testing: “SAMSHA Guidelines — Mandatory Federal Workplace Drug Testing Guidelines.”
Do Poppy Seeds Make You Test Positive For Weed
While poppy seeds don’t actually contain morphine, the seeds can become coated by, or absorb, opium extract during harvesting. Opium is the milky substance that is extracted along with the poppy seeds from the seed pod of the opium poppy after all the petals have fallen off.
The opium is composed of roughly 12 percent morphine, which is a narcotic that is prohibited in-competition. According to the World Anti-Doping Agency (WADA) Prohibited List, morphine is a threshold substance, meaning that WADA-accredited laboratories determine if a sample is positive for morphine when the level of morphine in the urine is greater than *1.3 micrograms/mL.
Can the morphine from poppy seeds be detected in a sample?
Research shows that morphine and codeine can sometimes be detected in the urine up to 48 hours after ingestion of poppy seeds from some pastries, such as bagels, muffins, and cakes (see reference one for a free article on this topic).
Even though most of the opium is removed from the poppy seeds during processing (usually more than 90%), in some cases, the seeds sold for use in foods still have a significant amount of opium – and thus morphine – on them. The amount of morphine residue left on the seeds depends on how well the poppy seeds are cleaned and processed, which varies depending on the country the seeds are from and how and when they were harvested.
Can athletes eat poppy seeds without testing positive?
USADA cannot predict the amount of poppy seeds you can eat and remain below the testing threshold set by WADA. **In most cases, consumption of poppy seeds in foods will not cause a positive doping test.
However, it may be possible to exceed the morphine threshold by eating foods with poppy seeds and USADA can’t predict how long morphine or morphine metabolites from poppy seeds will stay in your system. The most conservative approach would be to avoid poppy seeds a few days before and during competitions.
Thevis M, Opfermann G, Schänzer W. Urinary Concentrations of Morphine and Codeine After Consumption of Poppy Seeds. J Anal Toxicol (January-February 2003) 27(1): 53-56 . URL: http://www.ncbi.nlm.nih.gov/pubmed?term=morphine%20and%20codeine%20on%20poppy%20seeds%20thevis
Lachenmeier DW, Sproll C, Musshoff F. Poppy seed foods and opiate drug testing—where are we today? Ther Drug Monitor. 2010 Feb; 32(1): 11-18.
Moeller MR, Hammer K, Engel O. Poppy seed consumption and toxicological analysis of blood and urine samples. Forensic Sci Int. 2004 Jun 16; 143(2-3): 183-186.