Entourage Effect is crucial to achieving when extracting & purifying CBD because the synergic effect of cannabinoids & terpenes makes a huge difference. The entourage effect describes unique synergy achieved by all cannabinoids and terpenes in the cannabis plant. What does the entourage effect mean for CBD users? This article will provide you with everything you need to know about the whole-plant concept. An Explanation of One of the Most Powerful Medicinal Discoveries: The Entourage Effect Full-spectrum is one of the most popular buzzwords in the CBD industry, but what does it mean? It appears front and center on many CBD products, including ours, but why? What is the Entourage Effect and why is it so important?
Entourage Effect & CBD Oil: How the Synergic Effect Enhances CBD
The Entourage Effect is the term used to describe the enhanced effects of cannabinoids, such as CBD, when multiple compounds synergistically work together rather than alone. That synergistic effect is known as the Entourage Effect.
Everyone just knows about CBD or THC, but hemp contains much more than just those two cannabinoids.
Imagine two basketball teams playing against each other. Team red has only one player doing all the shooting, stealing, defending, and rebounding, while team blue has all five players working together doing different things. Which team would win? Obviously team blue will win.
Not All Hemp Extracts Are Equal
Just because two companies manufacture CBD oil does not mean the quality is close in terms of effectiveness and safety.
CBD oil from one company is not the same CBD oil as another. It’s important to understand that many variables come into play to manufacture CBD extracts.
The hemp plants’ genetics, the extraction method, and the parameters used, and the purification process are three of the several crucial parts of the manufacturing process.
The first two parts mentioned can be exceptional. Still, if the purification process cannot retain the essential cannabinoids and lighter compounds such as terpenes and flavonoids, it doesn’t make much of a difference.
Purchasing from a reputable company with extensive knowledge and experience in hemp extraction is crucial to getting a safe but effective product.
Entourage Effect: What Research Shows
It started In 1998 when Professors Raphael Mechoulam and Shimon Ben-Shabat found the Endocannabinoid System demonstrated an “entourage effect” when they noticed the plant compounds significantly increased the activity of our receptors.
These receptors, which interact with our Endocannabinoid System, play a crucial role in regulating and balancing many body processes such as immune response, communication between cells, sleep cycles, memory, and more.
In 2001, two highly notable researchers John McPartland and Ethan Russo, published a paper titled “Cannabis and Cannabis Extracts: Greater Than the Sum of Their Parts.”
This research paper further examines the claims of Professors Mechoulam and Ben-Shabat on how cannabinoids act with secondary compounds, such as terpenes and flavonoids.
Their research found supporting evidence that extracts rich in both cannabinoids and terpenes increased pharmacological activities that strengthened and broadened clinical applications and improved the therapeutic index.
To summarise, terpenes enhance the effects of cannabinoids, and having terpenes intact with cannabinoids shows a noticeable difference in effects.
More than Just CBD – Cannabinoids, Terpenes, and Flavonoids
What are “minor cannabinoids”?
Minor cannabinoids are cannabinoids, just like CBD or THC, found in hemp. Since they are found in much smaller amounts, ranging from 0.01mg to 5-7mg per 1,000mg of extract, they’re considered “minor” cannabinoids.
Although found in minor amounts, they still play a crucial role in the synergistic effects of CBD products. You would be surprised at how they always make a difference even at those minor amounts.
Research studies of minor cannabinoids lacks compared to CBD. However, they still show promising results for what we know. Here are three cannabinoids of the 113 scientists have discovered to date:
What is Cannabigerol (CBG)
CBG is the final form of CBGA, which is sometimes called the “stem cell” cannabinoid. Scientists have researched the potential antimicrobial and digestive benefits of CBG.
What is Cannabinol (CBN)
CBN can be produced by aging THC or converting CBD. Many people who use CBN believe that this cannabinoid has sleep-promoting properties, and CBN has been investigated for its potential neuroprotective benefits.
CBC is a little-known cannabinoid that has been investigated for its potential analgesic benefits. Scientists have researched the activity of CBC at the nervous system’s TRPV1 receptors, which regulate inflammation and pain.
Other notable cannabinoids are Cannabidiolic Acid (CBDA), Cannabidivarin (CBDV), Cannabicitran (CBT), or Tetrahydrocannabivarin (THCV).
What are Terpenes?
Terpenes are another group of chemical compounds found in hemp and are an essential group of aromatic compounds that give plants their unique fragrance. They’re present in nearly every plant on earth, and anything you can sense and smell from a plant is due to the terpenes present in the plant.
Health Benefits of Terpenes and Role with Cannabinoids
Not only do terpenes play a crucial role in the Entourage Effect, but they hold a wide range of health benefits. Medicinal properties like anticancer, antimicrobial, antifungal, antiviral, antihyperglycemic, analgesic, anti-inflammatory, and antiparasitic.
Here are three terpenes and their benefits:
What is Beta-Caryophyllene
Since it interacts with your brain’s CB2 receptors, beta-caryophyllene works like a cannabinoid. It doesn’t get you high, however, and this terpene is believed to have potent anti-inflammatory benefits.
What is Linalool
Found in lavender as well as hemp, linalool appears to have impressive antimicrobial benefits. This terpene also interacts with your nervous system, and it might help with depression and anxiety.
What is Guaiol
Guaiol has a piney flavor and aroma, and this terpene may offer antiparasitic benefits. Like many other terpenes, guaiol also appears to have antioxidant effects.
What are Flavonoids?
Cannabinoids and terpenes have been showing to take all the spotlight as cannabis and CBD products are being widely used. First, people learn about the other cannabinoids—outside of THC or CBD—then they learn about these fantastic compounds called terpenes. However, there is more that contributes to the entourage effect—flavonoids.
Flavonoids are a group of phytonutrients found in all sorts of fruits, flowers, vegetables, and of course, cannabis & hemp. The primary function of flavonoids is to serve as cell messengers and is also known for giving the plant pigment.
Flavonoids make the yellow of sunflower pop out against a sunny blue sky and give blueberries their name. However, studies have shown these compounds possess many health benefits.
Scientists have identified thousands of them throughout nature, and some are known to be only found in cannabis and hemp. The flavonoids found in hemp and marijuana are called cannaflavins .
In a study conducted in 2011 , they found flavonoids to posses the following properties:
- Lowers risk of heart disease
Summary on Entourage Effect: Enhancing the Effects of CBD Oil
Cannabinoids work better with a combination of cannabinoids, terpenes, and flavonoids versus a CBD product with fewer compounds or, even worse, just pure CBD.
Don’t forget the analogy of the two basketball teams. Which team do you think would win? The team with five players working together to shoot, pass, defend, rebound, or the team with just one player doing everything?
Obviously, the team with five players working together would win.
Why Choose Colorado Botanicals
Our team at Colorado Botanicals holds decades of experience in each part of the hemp manufacturing process. From the farms to growing hemp organically, the post-process of farming in drying the plants to the crucial extraction and purification process to retain as many cannabinoids, terpenes, flavonoids, and other important plant oils as possible.
If you’re looking for a product that maximizes the full potential of the Entourage Effect, visit our wide variety of products such as our CBD oils , CBD gummies , CBD creams , CBD softgels , or our CBD face mask.
Manufacturing of CBD extracts is not a fixed process, and not all extracts are equal.
To learn more about our high standards and process from seed to exact, make sure to check out our Quality page and our Quality and Consistency blog post. If you want to dive deeper into what makes the best CBD oil, then check out this blog post .
The goal is to extract the most beneficial compounds: the cannabinoids, terpenes, and flavonoids, with the least heat degradation. All while eliminating unwanted compounds such as the gums, lipids, heavy metals, pesticides, and so on.
CBD Entourage Effect: What Is It & How It Works with Other Cannabinoids
The entourage effect is one of the most intriguing discoveries in recent times when it comes to cannabis plants and their compounds. Proponents of the entourage effect claim that extracts produced from the whole cannabis plant increase the efficacy of its health benefits — something that would be unachievable with isolated compounds.
Scientists have contradictory views on this concept. There are clear indications that full-spectrum cannabis extracts are more effective in certain cases than their isolated counterparts. The advocates of isolating specific compounds and standardizing dosages aren’t so positive about these findings, claiming that attributing the entourage effect to all situations is a far-reaching generalization.
A full-spectrum product in the world of cannabis includes cannabinoids — even traces of THC — terpenes, and other compounds. There are also broad-spectrum extracts and isolates. The broad-spectrum is like a “light” version of full-spectrum because it contains all the aforementioned substances except for THC. Isolates, in turn, refers to pure cannabinoids that have been separated from the remaining constituents of cannabis. These are flavorless and odorless products that are sold in powders or infused into different items.
In this article, we’ll focus specifically on the entourage effect; this will be the most detailed yet to-the-point guide you’ll ever read, so even when you’re done with the text, save it for later and share it with friends to increase their awareness about different CBD spectra.
What Makes Cannabinoids and Terpenes So Special?
Cannabinoids and terpenes are the active ingredients of cannabis that work synergistically to amplify the health benefits of each other. Cannabis researchers call it “the entourage effect.”
The debate has usually revolved around THC vs CBD, and comparing which one is better. But in fact, we should look at them as complementary compounds that can help you get the most out of your cannabis use.
Believe it or not, there’s a whole lot going on in the plant on a molecular level.
But how does one decode the term “entourage effect?” What is the role of the other 113 cannabinoids and 200 terpenes?
Find your answers in the next section.
What is the Entourage Effect in CBD?
In very simple terms, the entourage effect helps maximize the health benefits of CBD oil. It occurs when all the compounds within the cannabis plant interact with our bodies, producing stronger effects than they would if a person took them in isolation. These stronger effects are referred to as a “synergy.”
The entourage effect was first mentioned by two scientists in 1998 — Raphael Mechoulam and Shimon Ben-Shabat. They suggested that the endocannabinoid system (ECS) manifested “the entourage effect.” (1) According to the authors of the study, various “inactive” compounds and related molecules enhanced the activity of the major endogenous cannabinoids: 2-AG and anandamide. Mechoulam and Ben-Shabat said their discovery made it clear why botanical medications were often more effective than synthetic isolates.
For CBD oil users, it means that CBD isn’t the only compound responsible for the health benefits you experience. If you feel stronger relief from the stress of physical discomfort using a full-spectrum CBD oil, this may be caused by the synergistic effects provided by other cannabinoids, such as CBD, CBDV, CBG, CBC, or CBN, and terpenes such as beta-caryophyllene, limonene, myrcene, or linalool.
While CBD is a powerful compound on its own, it needs a team of supporters to develop its full potential.
Terpenes are fascinating molecules, and we’re going to devote an entire section to them, but before we make it there, let’s take a look at the most well-known entourage effect between CBD and THC.
THC & CBD: The Most Well-Known Cannabis Entourage Effect
One of the first observed and most cited entourage effects is the relationship between CBD and THC.
While THC, the cannabinoid that gets you high, binds directly to the CB1 cannabinoid receptors in the brain, CBD uses different mechanisms to manifest its effects. When you take these two compounds together, CBD reduces THC’s psychotic potential by blocking the sites of the CB1 receptors to which THC tries to bind. As a result, you feel less high than you would if you consumed THC alone.
The evidence supporting CBD’s ability to help take the edge off THC is piling up. In the 1980s, the Food and Drug Administration (FDA), approved a synthetic form of THC known as Marinol. While the medication did a decent job of increasing patients’ appetite, it also had side effects such as paranoia. Another FDA-approved drug, Sativex, contains both CBD and THC in a 1:1 ratio, so patients can tolerate it without getting too stoned.
Once you understand the interaction between CBD, THC, and the CB1 receptor, you should get a general idea of how the entourage effect works.
THC is the agonist of this receptor, meaning it works like a key that unlocks the receptor’s lock. CBD isn’t a direct agonist of the CB1 receptor, but it competes with THC for its space. As mentioned, taking these two compounds together leaves fewer receptors for THC to activate. In this scenario, the potential side-effects of THC, such as anxiety and paranoia, are modulated.
Adie Wilson-Poe, a professor at Washington University (St. Louis) says that CBD uses a minimum of 14 different mechanisms of action in the central nervous system alone. Aside from that, it has over 65 molecular targets. CBD acts through a myriad of pathways, so it’s hard to link its health benefits solely to CB1 occupation.
Now, when you take full-spectrum CBD oil, there are a lot more compounds entering your body. Using full-spectrum products activates legions of beneficial molecules at the same time.
Benefits of THC-Only Products
Please note that we cannot make any health claims regarding cannabis compounds. We always encourage you to do your own research and explore the world of cannabinoids and terpenes. Below we only share information about the potential benefits of THC-only and CBD-only products.fg
The benefits of THC include:
- Deep relaxation
- Relief from stress
- Reduced discomfort and stiffness
- Regulation of the sleep cycle
- Modulation of the gut microbiome
- Improved appetite
THC effects usually reach their peak when you consume an edible. When you eat a cannabis brownie, for example, THC gets metabolized in the liver, transforming into 11-hydroxy-THC. This metabolite is five times stronger than THC. So, when you smoke cannabis and take 10 mg of THC, it enters your lungs and goes to the bloodstream through the lung tissue. A 10 mg THC edible translates to 50 mg of THC when it comes to its potency.
Benefits of CBD-Only Products
CBD has very different effects from THC. The most vivid example is the lack of intoxication. It is the compound of choice for those who don’t tolerate THC well or are afraid of failing a drug test. Cannabidiol is also great for general supplementation because it supports the proper functioning of the endocannabinoid system.
CBD is mostly used to relieve:
- Sleep deprivation
- Physical discomfort
- Endocannabinoid deficiencies
CBD also has a strong affinity with the immune system, regulating communication between immune cells and improving its performance.
What Happens When You Start to Use Whole-Plant Products?
The modulation of the psychoactive effects of THC is a significant benefit of the entourage effect, but the whole-plant concept is about more than that. Full-spectrum products can improve the overall efficacy of cannabinoids. The main reason why this is a new discovery is the lack of research regarding the health benefits of cannabis due to its prohibition. The minor cannabinoids, as well as terpenes, have many positive effects of their own, but it’s difficult to gauge the efficacy of certain entourage effects with different ratios of these compounds.
From our perspective, it’s rather a matter of the entourage effect making everything better rather than isolates being less effective — as far as preliminary research shows.
Evidence of the Entourage Effect
There’s a lot of science to support the higher efficacy of full-spectrum CBD. In 2011, Ethan Russo, one of the most esteemed cannabis researchers, published an important study in the British Journal of Pharmacology (2). In the study, Russo wrote that cannabinoids and terpenes produce synergistic effects that translate to better therapeutic effects.
Russo also conducted a more recent study published in the journal Frontiers in Plant Science in 2019 (3). He reviewed multiple studies that investigated the case for the Entourage effect. Russo concluded that there is strong evidence to suggest that the phytochemical factory in cannabis is more beneficial for humans than isolates.
In contrast, a study by Santiago et al., published in Biorxiv in 2019, claimed that there is no such thing as the entourage effect (4). The authors of the study analyzed the responses of cells transfected with human cannabinoid receptors (CB1 and CB2) in the presence of THC and a few selected terpenes.
The authors found that the receptors were not altered by any of these compounds, whether they coexisted together or were used in separation. However, the authors also admitted limitations to their research. The main concern was the fact that the team only focused on a single CB1 and CB2 pathway.
What Are Terpenes?
Most people think about fragrances and flavors in herbs when they hear the word “terpenes.”
However, the research conducted over the last few years have shown that terpenes are potent therapeutic molecules. That’s because they are responsible for starting the entourage effect in the cannabis plant.
Terpenes are volatile aromatic substances that evaporate easily and provide plants, fruits, vegetables, and spices with their unique aromas. The more aromatic the plant, the more terpenes are in it.
If you’ve ever wondered why cannabis strains smell differently but still have some characteristics similar to other plants — the answer is “terpenes.”
So far, we know about 200 terpenes in cannabis, but only a few of them occur in concentrations large enough to be worth mentioning.
Terpenes can be broken down into three groups:
Whether a specific terpene falls into one of these categories depends on the number of repeating units of a 5 carbon molecule known as isoprene, the structural marker of all terpenes.
10 Most Commonly Found Terpenes in Cannabis
As mentioned earlier, only a few terpenes are found in amounts substantial enough to mention them in this text:
Here are the 10 most commonly found terpenes in the cannabis plant:
Health Benefits of Terpenes
It is true that terpenes influence the aromas of plants, but there’s a growing body of evidence that they have a plethora of health benefits — especially when consumed along with cannabinoids such as CBD.
The list of potential health benefits of terpenes include:
- Reduced stress
- Appetite control
- Relief from physical discomfort
- Cognitive boost
- Better blood circulation
- Modulation of nausea and vomiting
- Protection of healthy cells
Needless to say, these effects are stronger when put together in a cannabis extract such as full-spectrum CBD oil.
Final Thoughts on the Entourage Effect
The entourage effect has garnered a lot of attention recently. If this concept is true for all cannabis extracts, it may change the way people use hemp and marijuana-based products forever. However, the existence of this phenomenon doesn’t necessarily mean that broad-spectrum CBD or CBD isolate is inferior to full-spectrum products. There are cases where the entourage effect isn’t the desired effect.
Nevertheless, the concept that cannabinoids and terpenes are more powerful together than on their own is an intriguing one. In an interesting video, Dr. Sean McAllister evaluates the effects of THC and CBD on tumor growth. He suggests that using the two cannabinoids on cancerous cells in the lab leads to faster death of malignant cells while protecting the healthy ones.
The real challenge faced by scientists is to find out how we can possibly leverage the entourage effect by manipulating the ratios of cannabinoids and terpenes. When we get a deeper understanding of this phenomenon, we could adjust different forms of CBD to specific needs. Now that’s what we call personalized science!
An Explanation of One of the Most Powerful Medicinal Discoveries: The Entourage Effect
Full-spectrum is one of the most popular buzzwords in the CBD industry, but what does it mean? It appears front and center on many CBD products, including ours, but why? What is the so-called Entourage Effect and why is it so important? This blog post examines the scientific benefits of full-spectrum CBD products and the Entourage Effect.
A full-spectrum product contains CBD along with all of the other minor cannabinoids and terpenes naturally produced by the hemp plant. That is, it contains the full-spectrum of hemp compounds. Fitting name, right? This is in contrast to broad-spectrum and isolate products. Broad-spectrum products contain CBD and all minor cannabinoids except THC. Isolate products contain only CBD. Full-spectrum oils are the truest representation of the hemp plant, and the most therapeutic. This is where understanding the Entourage Effect comes into play.
The Entourage Effect: 1 + 1 = 3
The Entourage Effect is a term for the synergistic benefit derived from all compounds found in the hemp plant. CBD is just one beneficial cannabinoid, but paired with THC, minor cannabinoids, terpenes, and other hemp compounds, a greater therapeutic benefit is achieved than any one compound in isolation.
CBD, THC, minor cannabinoids, and even some terpenes all interact with your Endocannabinoid System (ECS). Your ECS regulates a wide range of biological processes (sleep, appetite, memory, immune function, pain response to name a few). By pairing CBD with other compounds that interact with the ECS, it increases the effectiveness of CBD.
Dr. Ethan Russo is a leader in medicinal cannabis research and has shared multiple papers supporting the Entourage Effect. Many users have experienced little to no benefit from CBD isolate products, but have been helped greatly by full-spectrum products due to the Entourage Effect.
Why is CBD with THC Better?
Full-spectrum CBD oil containing THC and other cannabinoids is far superior to CBD oils containing just CBD. THC is typically the most abundant compound (outside of CBD) in CBD oil. THC contributes greatly to the therapeutic effects of CBD, even in low concentrations that don’t lead to intoxication (e.g. 0.3% for hemp products). This is due to the Entourage Effect.
All BATCH products, except for our Muscle Gel, contain full-spectrum CBD oil. Using our in-house HPLC testing instrument, we’ve identified and quantified seven well-known cannabinoids found in our extracts: CBDV, CBDA, CBG, CBD, d9-THC, d8-THC, and CBC. Additionally, there are hundreds of lesser-known, and less abundant, cannabinoids that we don’t have the abilities to quantify. All of these cannabinoids further contribute to the healing powers of full-spectrum CBD products.
What Role Do Terpenes Play in the Entourage Effect?
Terpenes are a class of organic compounds that also contribute to the Entourage Effect. They are aromatic in nature, giving plants their scents. For example, pinene gives pine trees their distinctive smell. Limonene contributes to citrus fruits’ odor. These compounds are also found in the hemp plant. We all know how smelly the hemp plant can be! Some terpenes (e.g. beta-caryophyllene) interact directly with the Endocannabinoid System and can contribute to the Entourage Effect and the healing ability of CBD.
All of our CBD oil contains naturally occurring terpenes found in the hemp plant. In addition to this, we supplement our products with terpene isolates to dial up or down desired effects depending on the product application. This is how we formulate different effect-based blends like Clarity, Dream, Soothe, and Calm.
All CBD is Not Equal
The high price of CBD may motivate some customers to search for the cheapest available option. While we’re all for frugality, we also have to caution our customers. Make sure the CBD you are purchasing is indeed full-spectrum and backed up with lab results (preferably from a trusted third-party lab). Look for cannabinoids besides CBD on potency lab reports. Isolate products are typically cheaper, but lack the true power of the Entourage Effect. We highly recommend full-spectrum products for the highest therapeutic benefit.